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Fracture results across studies
In the Three-Year Study of FIT, FOSAMAX reduced the percentage of women experiencing at least one new radiographic vertebral fracture from 15.0% to 7.9% (47% relative risk reduction, p less than 0.001); in the Four-Year Study of FIT, the percentage was reduced from 3.8% to 2.1% (44% relative risk reduction, p equal to 0.001); and in the combined U.S./Multinational studies, from 6.2% to 3.2% (48% relative risk reduction, p equal to 0.034).
FOSAMAX reduced the percentage of women experiencing multiple (two or more) new vertebral fractures from 4.2% to 0.6% (87% relative risk reduction, p less than 0.001) in the combined U.S./Multinational studies and from 4.9% to 0.5% (90% relative risk reduction, p less than 0.001) in the Three-Year Study of FIT. In the Four-Year Study of FIT, FOSAMAX reduced the percentage of osteoporotic women experiencing multiple vertebral fractures from 0.6% to 0.1% (78% relative risk reduction, p equal to 0.035).
Thus, FOSAMAX reduced the incidence of radiographic vertebral fractures in osteoporotic women wFosamax necrosis
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August 7th, 2008 at 6:13 am
[…] in the last two years, several oral surgeons have become convinced that oral biphosphonates such as Fosamax can also cause jawbone death for others when taken over a long period of […]